Editorial for targets and anticancer drug research

Anticancer drug targets: approaching angiogenesis.

Aurora kinases as anticancer drug targets.

The human aurora family of serine-threonine kinases comprises three members, which act in concert with many other proteins to control chromosome assembly and segregation during mitosis. Aurora dysfunction can cause aneuploidy, mitotic arrest, and cell death. Aurora kinases are strongly expressed in a broad range of cancer types. Aurora A expression in tumors is often associated with gene amplif...

Editorial: Membrane domains as new drug targets

Citation: van Spriel AB, van den Bogaart G and Cambi A (2015) Editorial: Membrane domains as new drug targets. Our understanding of the plasma membrane of eukaryotic cells has profoundly changed over the past 40 years (Kusumi et al., 2012). It is now well-understood that at the plasma membrane lipids and proteins are not randomly distributed, but are highly organized in discrete membrane domain...

Editorial: Orphan GPCRs As Emerging Drug Targets

G protein coupled-receptors (GPCRs) have been proven to be the most successful class of druggable targets in the human genome. In fact, 30–50% of marketed drugs are estimated to exert their clinical effects via GPCRs. Furthermore, the pace of GPCR-targeted new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) in the recent years still remains to a level near its hi...

Targets in anticancer research--A review.

Cancer is a complex disease characterized by a loss in the normal cell regulatory mechanisms that govern cell survival, proliferation, and differentiation. Current chemotherapeutics, as anticancer agents, are developing resistance to single drug and also to treatment therapies involving multiple drugs. Cross resistance associated with the specificity and selectivity of existing drugs has restri...